Bruce Rosen, M.D., Ph.D.

Functional Magnetic Resonance Imaging

The program I direct is aimed at the development of magnetic resonance imaging in its widest possible applications for both diagnostic and physiologic studies. The area of diagnosis most applicable to the diabetic population relates to the further development of noninvasive methods for the measurement of vascular patency and tissue perfusion, in the cerebral, peripheral and (most challenging) coronary circulation.

References:

  1. Stufflebeam SM, Rosen BR. Mapping cognitive function: Imaging of the Mind Neuroimaging Clinics, Neuroimaging Clinics North America, 2007; 469-84

  2. 229. Kannurpatti SS, Biswal BB, Kim YR, Rosen BR. Spatio-temporal characteristics of low-frequency BOLD signal fluctuations in isoflurane-anesthetized rat brain.Neuroimage. 2008 May 1;40(4):1738-47.

  3. Raij T, Karhu J, Kici? D, Lioumis P, Julkunen P, Lin FH, Ahveninen J, Ilmoniemi RJ, Mäkelä JP, Hämäläinen M, Rosen BR, Belliveau JW. Parallel input makes the brain run faster.Neuroimage. 2008 May 1;40(4):1792-7. Epub 2008 Feb 14.  PMID: 18353681

  4. Witzel T, Lin FH, Rosen BR, Wald LL. Stimulus-induced Rotary Saturation (SIRS): a  potential method for the detection of neuronal currents with MRI. Neuroimage. 2008 Oct 1;42(4):1357-65. Epub 2008 May 20.  PMID: 18684643 [PubMed - in process

  5. Chen YI, Wang FN, Nelson AJ, Xu H, Kim Y, Rosen BR, Kwong KK.  Electrical stimulation modulates the amphetamine-induced hemodynamic changes: An fMRI study to compare the effect of stimulating locations and frequencies on rats.  Neurosci Lett.2008 Oct 24, 444(2):117-21. Epub 2008 Aug 15. PMID:18722508 [PubMed-in process]

  6. KimYR, Temima E, Huan S, Atochin DN, Dai G, Lo EH, Huang PL, Bogdanov A Jr, Rosen BR.  In vivo Quantification of transvascular water exchange during the acute Phase of permanent stroke. Magn Reson Med. 2008 Oct;60(4):813-21

  7. DevorA, Hillman EM, Tian P, Waeber C, Teng IC, Ruvinshaya L, Shalinsky MH, Zhu H, Haslinger RH, Narayanan Sn, Ulbert I, Dunn AK, Lo EH, Rosen BR, Dale AM, Kleinfeld D, Boas DA. Stimulus-induced changes in blood flow and 2-Deoxyglucose uptake  dissociate in ipsilateral somatosensory cortex.J Neurosci.2008 Dec31;28(53):14347-57 PMID:19118167

  8. Huang S, Liu C, Dai G, Kim YR, Rosen, BR. Manipulation of tissue contrast using contrast agents for enhanced MR microscopy in ex vivo mouse brain. Neuroimage 2009 Mar 2. [Epub ahead of print] PMID:19264139

 

 
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