BADERC-Bruce Rosen

Bruce Rosen, M.D., Ph.D.

Functional Magnetic Resonance Imaging

The program I direct is aimed at the development of magnetic resonance imaging in its widest possible applications for both diagnostic and physiologic studies. The area of diagnosis most applicable to the diabetic population relates to the further development of noninvasive methods for the measurement of vascular patency and tissue perfusion, in the cerebral, peripheral and (most challenging) coronary circulation.

References:

1. Aronen HJ, PardoFS, Kennedy DN, Belliveau JW, Packard SD, Hsu DW, Hochberg FH, Fischman AJ, Rosen BR. High microvascular blood volume is associated with high glucose uptake and tumor angiogenesis in human gliomas. Clin Cancer Res. 2000; 6(6):2189-2200.

2. Ostergaard L,, Sorensen AG, Chesler DA, Weisskoff RM, Koroshetz WJ, Wu O, Gyldensted C, Rosen BR. Combined diffusion-weighted and perfusion-weighted flow heterogeneity magnetic resonance imaging in acute stroke. Stroke. 2000; 31:1097-1103.

3. Wu O, Koroshetz WJ, Ostergaard L, Buonanno FS, Copen WA, Gonzalez RG, Rordorf G, Rosen BR, Schwamm LH, Weisskoff RM, Sorensen AG. Predicting tissue outcome in acute human cerebral ischemia using combined diffusion- and perfusion-weighted MR imaging. Stroke. 2001; 32:933-942.

4. Hadjikhani N, Sanchez del Rio M, Wu O, Schwartz D, Bakker D, Fischl B, Kwong KK, Cutrer FM, Rosen BR, Tootell RBH, Sorensen AG, Moskowitz MA. Mechanisms of migrane aura revealed by functional MRI in human visual cortex. Proc Natl Acad Sci USA. 2001; 98(8):4687-4692.

5. Cramer SC, Nelles G, Kaplan JD, Finkelstein SP, Rosen BR. A functional MRI study of three motor tasks in the evaluation of stroke recovery. Neurorehab & Neur Rep. 2001;15:1-8.

6. Dijkhuizen RM, Asahi M, Rosen BR, Lo EH. Delayed rt-PA treatment in a rat embolic stroke model: Diagnosis and prognosis of ischemic injury and hemorrhagic transformation with magnetic resonance imagng. J Cereb Blood Flow Met. 2001; 21:964-971.

7. Dijkhuizen RM, Asahi M, Wu O, Rosen BR, Lo EH. Rapid breakdown of microvascular barriers and subsequent hemorrhagic transfformation after delayed recombinant tissue plasminogen activator treatment in a rat embolic stroke model. Stroke 2002; 33:2100-2104.

8. Sperling RA, Bates JF, Chua EF, Cocchiarella AJ, Rentz DM, Rosen BR, Schacter DL, Albert MS: fMRI studies of associative encoding in young and elderly controls and mild Alzheimer’s disease. J Neurol Neurosurg Psychiatry 2003;74:44-50.

9. Boas DA, Strangman G, Culver JP, Hoge RD, Jasdzewski G, Poldrack RA, Rosen BR, Mandeville JB. Can the cerebral metabolic rate of oxygen be estimated with near-infrared spectroscopy? Phys Med Biol. 2003;48:2405-18.






			Bruce Rosen, M.D., Ph.D. Functional Magnetic Resonance Imaging The program I direct is aimed at the development of magnetic resonance imaging in its widest possible applications for both diagnostic and physiologic studies. The area of diagnosis most applicable to the diabetic population relates to the further development of noninvasive methods for the measurement of vascular patency and tissue perfusion, in the cerebral, peripheral and (most challenging) coronary circulation. References: 1. Aronen HJ, PardoFS, Kennedy DN, Belliveau JW, Packard SD, Hsu DW, Hochberg FH, Fischman AJ, Rosen BR. High microvascular blood volume is associated with high glucose uptake and tumor angiogenesis in human gliomas. Clin Cancer Res. 2000; 6(6):2189-2200. 2. Ostergaard L,, Sorensen AG, Chesler DA, Weisskoff RM, Koroshetz WJ, Wu O, Gyldensted C, Rosen BR. Combined diffusion-weighted and perfusion-weighted flow heterogeneity magnetic resonance imaging in acute stroke. Stroke. 2000; 31:1097-1103. 3. Wu O, Koroshetz WJ, Ostergaard L, Buonanno FS, Copen WA, Gonzalez RG, Rordorf G, Rosen BR, Schwamm LH, Weisskoff RM, Sorensen AG. Predicting tissue outcome in acute human cerebral ischemia using combined diffusion- and perfusion-weighted MR imaging. Stroke. 2001; 32:933-942. 4. Hadjikhani N, Sanchez del Rio M, Wu O, Schwartz D, Bakker D, Fischl B, Kwong KK, Cutrer FM, Rosen BR, Tootell RBH, Sorensen AG, Moskowitz MA. Mechanisms of migrane aura revealed by functional MRI in human visual cortex. Proc Natl Acad Sci USA. 2001; 98(8):4687-4692. 5. Cramer SC, Nelles G, Kaplan JD, Finkelstein SP, Rosen BR. A functional MRI study of three motor tasks in the evaluation of stroke recovery. Neurorehab & Neur Rep. 2001;15:1-8. 6. Dijkhuizen RM, Asahi M, Rosen BR, Lo EH. Delayed rt-PA treatment in a rat embolic stroke model: Diagnosis and prognosis of ischemic injury and hemorrhagic transformation with magnetic resonance imagng. J Cereb Blood Flow Met. 2001; 21:964-971. 7. Dijkhuizen RM, Asahi M, Wu O, Rosen BR, Lo EH. Rapid breakdown of microvascular barriers and subsequent hemorrhagic transfformation after delayed recombinant tissue plasminogen activator treatment in a rat embolic stroke model. Stroke 2002; 33:2100-2104. 8. Sperling RA, Bates JF, Chua EF, Cocchiarella AJ, Rentz DM, Rosen BR, Schacter DL, Albert MS: fMRI studies of associative encoding in young and elderly controls and mild Alzheimer’s disease. J Neurol Neurosurg Psychiatry 2003;74:44-50. 9. Boas DA, Strangman G, Culver JP, Hoge RD, Jasdzewski G, Poldrack RA, Rosen BR, Mandeville JB. Can the cerebral metabolic rate of oxygen be estimated with near-infrared spectroscopy? Phys Med Biol. 2003;48:2405-18.