BADERC- Janet Hall

Janet Hall, M.D

Nutritional and Metabolic Control of Reproduction

Dr. Hall is a clinical investigator whose research focuses on the neuroendocrine interactions underlying normal human reproduction, the changes that occur both with aging and in clinical disorders of ovulation as well as the interrelationships between metabolic signals and the reproductive systems. Her recent studies of the physiology and pathophysiology of the menstrual cycle have helped to define the physiology of inhibin A and inhibin B relative to that of estradiol in young and older reproductive aged women; have determined the influence of estradiol on leptin, body composition and energy balance; have defined the interactions of insulin and LH as determinants of the inverse relationship of inhibin B and body mass index in patients with polycystic ovarian syndrome (PCOS); defined the characteristics that predispose to success in ovulation induction using pulsatile GnRH in women with PCOS; and determined that mild degrees of hyperandrogenism and insulin resistance are present in women with polycystic ovarian morphology and a longstanding history of regular ovulatory menstrual cycles. Current studies are underway to further explore the mechanism underlying the inverse relationship between LH and BMI in PCOS and to explore the circadian regulation of leptin in normal women. Dr. Hall is also Associate Director of the Education Unit of the MGH Clinical Research Program and Vice-President for Clinical Research of the Endocrine Society. A recipient of the A. Clifford Barger Excellence in Mentoring Award from Harvard Medical School.

1. Hall JE, Taylor AE, Hayes FJ, Crowley WF Jr. Insights into hypothalamic-pituitary dysfunction in polycystic ovarian syndrome. J Endocr Invest 1998; 21: 602-611.

2. Lavoie HB, Taylor AE, Sharpless JL, Anderson AJ, Strauss CC, Hall JE. Effects of short-term hormone replacement on serum leptin levels in postmenopausal women. Clin Endocrinol 1999;51:415-422.

3. Anderson EJ, Lavoie HB, Strauss CC, Hubbard JL, Sharpless JL, Hall JE. Body composition and energy balance: lack of effect of short-term hormone replacement in younger and older postmenopausal women. Metabolism 2001;50:265-269.

4. Gill S, Taylor AE, Martin KA, Welt CK, Adams JM, Hall JE. Specific factors predict the response to pulsatile gonadotropin-releasing hormone (GnRH) therapy in polycystic ovarian syndrome (PCOS). J Clin Endocrinol Metab 2001;86:2428-2436.

5. Welt CK, Taylor AE, Martin KA, Hall JE. Serum inhibin B in polycystic ovarian syndrome: regulation by insulin and LH. J Clin Endocrinol Metab. 2002;87:5559-5565.

6. Adams JM, Taylor AE, Crowley WF Jr, Hall JE. Polycystic ovarian morphology with regular ovulatory cycles: insights into the pathophysiology of polycystic ovarian syndrome (PCOS). 2004 J Clin Endocrinol (in press).

7. Hall JE. Gonaodtropin secretion in PCOS. In: Updates in Infertility Treatment. Filicori M (ed) Monduzzi Editore, Bologna 2004 (in press).






			Janet Hall, M.D Nutritional and Metabolic Control of Reproduction Dr. Hall is a clinical investigator whose research focuses on the neuroendocrine interactions underlying normal human reproduction, the changes that occur both with aging and in clinical disorders of ovulation as well as the interrelationships between metabolic signals and the reproductive systems. Her recent studies of the physiology and pathophysiology of the menstrual cycle have helped to define the physiology of inhibin A and inhibin B relative to that of estradiol in young and older reproductive aged women; have determined the influence of estradiol on leptin, body composition and energy balance; have defined the interactions of insulin and LH as determinants of the inverse relationship of inhibin B and body mass index in patients with polycystic ovarian syndrome (PCOS); defined the characteristics that predispose to success in ovulation induction using pulsatile GnRH in women with PCOS; and determined that mild degrees of hyperandrogenism and insulin resistance are present in women with polycystic ovarian morphology and a longstanding history of regular ovulatory menstrual cycles. Current studies are underway to further explore the mechanism underlying the inverse relationship between LH and BMI in PCOS and to explore the circadian regulation of leptin in normal women. Dr. Hall is also Associate Director of the Education Unit of the MGH Clinical Research Program and Vice-President for Clinical Research of the Endocrine Society. A recipient of the A. Clifford Barger Excellence in Mentoring Award from Harvard Medical School. 1. Hall JE, Taylor AE, Hayes FJ, Crowley WF Jr. Insights into hypothalamic-pituitary dysfunction in polycystic ovarian syndrome. J Endocr Invest 1998; 21: 602-611. 2. Lavoie HB, Taylor AE, Sharpless JL, Anderson AJ, Strauss CC, Hall JE. Effects of short-term hormone replacement on serum leptin levels in postmenopausal women. Clin Endocrinol 1999;51:415-422. 3. Anderson EJ, Lavoie HB, Strauss CC, Hubbard JL, Sharpless JL, Hall JE. Body composition and energy balance: lack of effect of short-term hormone replacement in younger and older postmenopausal women. Metabolism 2001;50:265-269. 4. Gill S, Taylor AE, Martin KA, Welt CK, Adams JM, Hall JE. Specific factors predict the response to pulsatile gonadotropin-releasing hormone (GnRH) therapy in polycystic ovarian syndrome (PCOS). J Clin Endocrinol Metab 2001;86:2428-2436. 5. Welt CK, Taylor AE, Martin KA, Hall JE. Serum inhibin B in polycystic ovarian syndrome: regulation by insulin and LH. J Clin Endocrinol Metab. 2002;87:5559-5565. 6. Adams JM, Taylor AE, Crowley WF Jr, Hall JE. Polycystic ovarian morphology with regular ovulatory cycles: insights into the pathophysiology of polycystic ovarian syndrome (PCOS). 2004 J Clin Endocrinol (in press). 7. Hall JE. Gonaodtropin secretion in PCOS. In: Updates in Infertility Treatment. Filicori M (ed) Monduzzi Editore, Bologna 2004 (in press).