Clinical and molecular studies of Pediatric Carbohydrate Metabolism

Dr.   Levitsky’s laboratory examines the transcription factors controlling the development and function of the pancreatic beta cell, with the objective of being to be able to recreate beta cell function in cognate nonBeta cells or in stem cells.  She also is a co-investigator in  clinical studies of the treatment of type 2 diabetes in children as a member of the National Institutes of Health Funded TODAY study, Treatment Options for Children and Adolescents with Type 2 diabetes, and in studies of the use of CD3 antibody to prolong the remission phase in Type 1 diabetes

References:

1.Huang J, Karakucuk V, Levitsky LL, Rhoads DB, Expression of HNF4a variants in pancreatic islets and Ins-1 b cells, , Diabetes Metab Res Rev. 2008, 24:533-43.

2.Sherry NA, Levitsky LL, Management of diabetic ketoacidosis in children and adolescents, Paediatr Drugs 2008:10, 209-15

3.Huang, J., Levitsky, L.L., Rhoads, D.B. Novel P2 promoter-derived HNF4a isoforms with different N-terminus generated by alternate exon insertion. Exp Cell Res. 2009 ,315(7):1200-11..

4.Levitsky LL, Misra M, Boepple PA, Hoppin AG. Adolescent obesity and bariatric surgery. Curr Opin Endocrinol Diabetes Obes. 2009 Feb;16(1):37-4