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Inflammation and Atherosclerosis

Dr. Peter Libby has a research interest in vascular biology with special reference to atherogenesis. His group studies normal and abnormal function of smooth muscle and endothelial cells using the tools of biochemistry and cell and molecular biology. Two major themes of investigation include the control extracellular matrix metabolism in the arterial wall and the immune and inflammatory functions of atheroma-associated cells. Specific projects currently underway include basic investigation of the regulation of gene expression in vascular endothelial and smooth muscle cells and mononuclear phagocytes using array and conventional technology, and study of the cellular mechanisms of atherogenesis and the thrombotic complications atheroma as well as accelerated transplantation-associated arteriosclerosis.

References:

1. Sukhova GK, Williams JK, Libby P. Statins reduce inflammation in atheroma of nonhuman primates independent of effects on serum cholesterol. Arterioscler Thromb Vasc Biol. 2002 Sep 1;22(9):1452-8.

2. Schonbeck U, Gerdes N, Varo N, Reynolds RS, Horton DB, Bavendiek U, Robbie L, Ganz P, Kinlay S, Libby P. Oxidized low-density lipoprotein augments and 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors limit CD40 and CD40L expression in human vascular cells. Circulation. 2002;106:2888-93.

3. Shi GP, Sukhova GK, Kuzuya M, Ye Q, Du J, Zhang Y, Pan JH, Lu ML, Cheng XW, Iguchi A, Perrey S, Lee AM, Chapman HA, Libby P. Deficiency of the cysteine protease cathepsin S impairs microvessel growth. Circ Res. 2003 Mar 21;92(5):493-500.

4. Libby P. Vascular biology of atherosclerosis: overview and state of the art.Am J Cardiol. 2003;91:3A-6A.

5. Dollery CM, Owen CA, Sukhova GK, Krettek A, Shapiro SD, Libby P. Neutrophil elastase in human atherosclerotic plaques: production by macrophages. Circulation. 2003;107:2829-36.

6. Libby P. Metformin and vascular protection: a cardiologist's view. Diabetes Metab. 2003;29(4 Pt 2):6S117-20.

7. Aikawa M, Libby P. The vulnerable atherosclerotic plaque: pathogenesis and therapeutic approach. Cardiovasc Pathol. 2004 May-Jun;13(3):125-38.

8. Sugiyama S, Kugiyama K, Aikawa M, Nakamura S, Ogawa H, Libby P. Hypochlorous Acid, a Macrophage Product, Induces Endothelial Apoptosis and Tissue Factor Expression. Involvement of Myeloperoxidase-Mediated Oxidant in Plaque Erosion and Thrombogenesis. Arterioscler Thromb Vasc Biol. 2004(in press)


	Peter Libby, M.D. Inflammation and Atherosclerosis Dr. Peter Libby has a research interest in vascular biology with special reference to atherogenesis. His group studies normal and abnormal function of smooth muscle and endothelial cells using the tools of biochemistry and cell and molecular biology. Two major themes of investigation include the control extracellular matrix metabolism in the arterial wall and the immune and inflammatory functions of atheroma-associated cells. Specific projects currently underway include basic investigation of the regulation of gene expression in vascular endothelial and smooth muscle cells and mononuclear phagocytes using array and conventional technology, and study of the cellular mechanisms of atherogenesis and the thrombotic complications atheroma as well as accelerated transplantation-associated arteriosclerosis. References: 1. Sukhova GK, Williams JK, Libby P. Statins reduce inflammation in atheroma of nonhuman primates independent of effects on serum cholesterol. Arterioscler Thromb Vasc Biol. 2002 Sep 1;22(9):1452-8. 2. Schonbeck U, Gerdes N, Varo N, Reynolds RS, Horton DB, Bavendiek U, Robbie L, Ganz P, Kinlay S, Libby P. Oxidized low-density lipoprotein augments and 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors limit CD40 and CD40L expression in human vascular cells. Circulation. 2002;106:2888-93. 3. Shi GP, Sukhova GK, Kuzuya M, Ye Q, Du J, Zhang Y, Pan JH, Lu ML, Cheng XW, Iguchi A, Perrey S, Lee AM, Chapman HA, Libby P. Deficiency of the cysteine protease cathepsin S impairs microvessel growth. Circ Res. 2003 Mar 21;92(5):493-500. 4. Libby P. Vascular biology of atherosclerosis: overview and state of the art.Am J Cardiol. 2003;91:3A-6A. 5. Dollery CM, Owen CA, Sukhova GK, Krettek A, Shapiro SD, Libby P. Neutrophil elastase in human atherosclerotic plaques: production by macrophages. Circulation. 2003;107:2829-36. 6. Libby P. Metformin and vascular protection: a cardiologist's view. Diabetes Metab. 2003;29(4 Pt 2):6S117-20. 7. Aikawa M, Libby P. The vulnerable atherosclerotic plaque: pathogenesis and therapeutic approach. Cardiovasc Pathol. 2004 May-Jun;13(3):125-38. 8. Sugiyama S, Kugiyama K, Aikawa M, Nakamura S, Ogawa H, Libby P. Hypochlorous Acid, a Macrophage Product, Induces Endothelial Apoptosis and Tissue Factor Expression. Involvement of Myeloperoxidase-Mediated Oxidant in Plaque Erosion and Thrombogenesis. Arterioscler Thromb Vasc Biol. 2004(in press)