Microvascular Function in Diabetes

Dr. Ido's research interest is microvascular cell biology in diabetes. His group focuses on finding mechanisms of AMP-activated protein kinase (AMPK) and SIRT1 in protecting cells from apoptosis caused by glucolipotoxicity in diabetes. The group utilizes cultured endothelial cell and pericytes to address effects of AMPK and SIRT1 in transcriptional factors activation. His group is close contact to groups of Dr. Neil Ruderman.

1. Ido Y, Carling D, Ruderman N. Hyperglycemia induced apoptosis in human umbilical vein endothelial cells (HUVEC): Inhibition by the AMP-activated protein kinase (AMPK) activation. Diabetes 51:159-167, 2002
   
   
2. Ido Y, Chang JR, and Williamson, JR. NADH augments blood flow in physiologically activated renal and visual cortex. Proc. Natl. Acad. Sci. USA 13,101(2): 653-8, 2004.
   
   
3. Cacicedo JM, Yagihashi N, Keany JF Jr, Ruderman NR, Ido Y. AMPK inhibits fatty acid induced increases in NF-kappa B transactivation in cultured human umbilical vein endothelial cells. BBRC 324: 1204, 2004.
   
   
4. Cacicedo JM, Benjachareowong S, Chou E, Ruderman NB, and Ido Y.  Palmitate-Induced Apoptosis in Cultured Bovine Retinal Pericytes: Roles of NAD(P)H Oxidase, Oxidant Stress, and Ceramide. Diabetes 2005 54: 1838-1845.
   
   
5. Ido, Y. Pyridine nucleotide redox abnormalities in diabetes. Antioxid Redox Signal. 2007 9:931-42
   
   
6. Lan F, Cacicedo JM, Ruderman N, Ido Y. SIRT1 modulation of the acetylation status, cytosolic localization and activity of LKB1; possible role in AMP-activated protein kinase activation. J Biol Chem 283:27628-35,2008