Yasuo Ido, M.D., D. Phil.

Dr. Ido's research interest is microvascular cell biology in diabetes. His goupr focus on finding mechanisms of AMP-activated protein kinase (AMPK) in protecting cells from apoptosis. The group utilize cultured endothelialcell and pericytes to address effects of AMPK in oxidatiave stress and transcriptional factors activation. His group is close contact to groups of Dr. Neil Runderman and Dr. Tornheim

References:

1. Dagher, Z., N. Ruderman, K. Tornheim, and Y. Ido, The effect of AMP-activated protein kinase and its activator AICAR on the metabolism of human umbilical vein endothelial cells. Biochem Biophys Res Commun, 1999. 265(1): p. 112-5.

2. Williamson, J.R., C. Kilo, and Y. Ido, The role of cytosolic reductive stress in oxidant formation and diabetic complications. Diabetes Res Clin Pract, 1999. 45(2-3): p. 81-2.

3. Vidal-Puig, A.J., D. Grujic, C.Y. Zhang, T. Hagen, O. Boss, Y. Ido, A. Szczepanik, J. Wade, V. Mootha, R. Cortright, D.M. Muoio, and B.B. Lowell, Energy metabolism in uncoupling protein 3 gene knockout mice. J Biol Chem, 2000. 275(21): p. 16258-66.

4. Dagher, Z., N. Ruderman, K. Tornheim, and Y. Ido, Acute regulation of fatty acid oxidation and amp-activated protein kinase in human umbilical vein endothelial cells. Circ Res, 2001. 88(12): p. 1276-82.

5. Y. Ido., K.C. Chang, W.S. Lejeune, R.J. Bjercke, K.M. Reiser, J.R. Williamson, and R.G. Tilton, Vascular dysfunction induced by AGE is mediated by VEGF via mechanisms involving reactive oxygen species, guanylate cyclase, and protein kinase C. Microcirculation, 2001. 8(4): p. 251-63.

6. Y. Ido., K. Chang, T.A. Woolsey, and J.R. Williamson, NADH: sensor of blood flow need in brain, muscle, and other tissues. Faseb J, 2001. 15(8): p. 1419-21.

7. Schmidt, R.E., D.A. Dorsey, L.N. Beaudet, S.B. Plurad, C.A. Parvin, K.E. Yarasheski, S.R. Smith, H.J. Lang, J.R. Williamson, and Y. Ido, Inhibition of sorbitol dehydrogenase exacerbates autonomic neuropathy in rats with streptozotocin-induced diabetes. J Neuropathol Exp Neurol, 2001. 60(12): p. 1153-69.

8. Han, J., S.R. Farmer, J.L. Kirkland, B.E. Corkey, R. Yoon, T. Pirtskhalava, Y. Ido, and W. Guo, Octanoate attenuates adipogenesis in 3T3-L1 preadipocytes. J Nutr, 2002. 132(5): p. 904-10.

9. Y. Ido., D. Carling, and N. Ruderman, Hyperglycemia-induced apoptosis in human umbilical vein endothelial cells: inhibition by the AMP-activated protein kinase activation. Diabetes, 2002. 51(1): p. 159-67.

10. Tomas, E., Y.S. Lin, Z. Dagher, A. Saha, Z. Luo, Y. Ido, and N.B. Ruderman, Hyperglycemia and insulin resistance: possible mechanisms. Ann N Y Acad Sci, 2002. 967: p. 43-51.

11. Ruderman, N.B., Cacicedo, J., Itani, S., Yagihashi, N., Saha, A.K., Ye, J., Chen, K., Zou, M., Carling, D., Cohen, R.A., Keaney, J.F., Jr., Kraegen, E.W., Ido, Y. Malonyl CoA and AMPK: Possible links between insulin resistance in muscle and early endothelial cell damage in diabetes. Biochem. Soc. Transactions. 31(Pt 1):202-6, 2003.

12. Y. Ido, K. Chang, J. R. Williamson. NADH augments blood flow in physiologically activated retina and visual cortex. Proc. Natl. Acad. Sci. USA 13;101(2):653-8, 2004.


	Yasuo Ido, M.D., D. Phil. Microvascular Function in Diabetes Dr. Ido's research interest is microvascular cell biology in diabetes. His goupr focus on finding mechanisms of AMP-activated protein kinase (AMPK) in protecting cells from apoptosis. The group utilize cultured endothelialcell and pericytes to address effects of AMPK in oxidatiave stress and transcriptional factors activation. His group is close contact to groups of Dr. Neil Runderman and Dr. Tornheim References: 1. Dagher, Z., N. Ruderman, K. Tornheim, and Y. Ido, The effect of AMP-activated protein kinase and its activator AICAR on the metabolism of human umbilical vein endothelial cells. Biochem Biophys Res Commun, 1999. 265(1): p. 112-5. 2. Williamson, J.R., C. Kilo, and Y. Ido, The role of cytosolic reductive stress in oxidant formation and diabetic complications. Diabetes Res Clin Pract, 1999. 45(2-3): p. 81-2. 3. Vidal-Puig, A.J., D. Grujic, C.Y. Zhang, T. Hagen, O. Boss, Y. Ido, A. Szczepanik, J. Wade, V. Mootha, R. Cortright, D.M. Muoio, and B.B. Lowell, Energy metabolism in uncoupling protein 3 gene knockout mice. J Biol Chem, 2000. 275(21): p. 16258-66. 4. Dagher, Z., N. Ruderman, K. Tornheim, and Y. Ido, Acute regulation of fatty acid oxidation and amp-activated protein kinase in human umbilical vein endothelial cells. Circ Res, 2001. 88(12): p. 1276-82. 5. Y. Ido., K.C. Chang, W.S. Lejeune, R.J. Bjercke, K.M. Reiser, J.R. Williamson, and R.G. Tilton, Vascular dysfunction induced by AGE is mediated by VEGF via mechanisms involving reactive oxygen species, guanylate cyclase, and protein kinase C. Microcirculation, 2001. 8(4): p. 251-63. 6. Y. Ido., K. Chang, T.A. Woolsey, and J.R. Williamson, NADH: sensor of blood flow need in brain, muscle, and other tissues. Faseb J, 2001. 15(8): p. 1419-21. 7. Schmidt, R.E., D.A. Dorsey, L.N. Beaudet, S.B. Plurad, C.A. Parvin, K.E. Yarasheski, S.R. Smith, H.J. Lang, J.R. Williamson, and Y. Ido, Inhibition of sorbitol dehydrogenase exacerbates autonomic neuropathy in rats with streptozotocin-induced diabetes. J Neuropathol Exp Neurol, 2001. 60(12): p. 1153-69. 8. Han, J., S.R. Farmer, J.L. Kirkland, B.E. Corkey, R. Yoon, T. Pirtskhalava, Y. Ido, and W. Guo, Octanoate attenuates adipogenesis in 3T3-L1 preadipocytes. J Nutr, 2002. 132(5): p. 904-10. 9. Y. Ido., D. Carling, and N. Ruderman, Hyperglycemia-induced apoptosis in human umbilical vein endothelial cells: inhibition by the AMP-activated protein kinase activation. Diabetes, 2002. 51(1): p. 159-67. 10. Tomas, E., Y.S. Lin, Z. Dagher, A. Saha, Z. Luo, Y. Ido, and N.B. Ruderman, Hyperglycemia and insulin resistance: possible mechanisms. Ann N Y Acad Sci, 2002. 967: p. 43-51. 11. Ruderman, N.B., Cacicedo, J., Itani, S., Yagihashi, N., Saha, A.K., Ye, J., Chen, K., Zou, M., Carling, D., Cohen, R.A., Keaney, J.F., Jr., Kraegen, E.W., Ido, Y. Malonyl CoA and AMPK: Possible links between insulin resistance in muscle and early endothelial cell damage in diabetes. Biochem. Soc. Transactions. 31(Pt 1):202-6, 2003. 12. Y. Ido, K. Chang, J. R. Williamson. NADH augments blood flow in physiologically activated retina and visual cortex. Proc. Natl. Acad. Sci. USA 13;101(2):653-8, 2004.