Vitamin D and the Prevention of type 2 diabetes

The program focuses on the role of vitamin D in prevention and treatment of type 2 diabetes ( The program is funded by NIH and ADA to conduct observational and randomized trials on prevention of type 2 diabetes. We are coordinating a large multi-center trial on vitamin D supplementation for prevention of type 2 diabetes ( and a second smaller 2-site trial on vitamin D supplementation for treatment of established type 2 diabetes. Tufts Medical Center also serves as a clinical site for both trials.


1. Pittas AG, Chung M, Trikalinos T, Mitri J, Brendel M, Patel K, Lichtenstein AH, Lau J, Balk EM.Vitamin D and Cardiometabolic Outcomes: A Systematic Review
Ann Intern Med. 2010 March 2; 152(5): 307–314. PMCID: PMC3211092

2. Mitri J, Dawson-Hughes B, Hu FB, Pittas AG. Effects of vitamin D and calcium supplementation on pancreatic β cell function, insulin sensitivity, and glycemia in adults at high risk of diabetes: the Calcium and Vitamin D for Diabetes Mellitus (CaDDM) randomized controlled trial. Am J Clin Nutr. 2011;94:486-94. PMCID:PMC3142723

3. Liu E, McKeown NM, Pittas AG, Meigs JB, Economos CD, Booth SL, Jacques PF. Predicted 25-hydroxyvitamin D score and change in fasting plasma glucose in the Framingham offspring study. Eur J Clin Nutr. 2012;66:139-41. PMCID: PMC3796766

4. Pittas AG, Nelson J, Mitri J, Hillmann W, Garganta C, Nathan DM, Hu FB and Dawson-Hughes B. Plasma 25-hydroxyvitamin D and progression to diabetes in patients at risk for diabetes: an ancillary analysis in the Diabetes Prevention Program. Diabetes Care 2012:35(3):565-573. PMC3322702.

5. Song Y, Wang L, Pittas AG, Del Gobbo LC, Zhang C, Manson JE, and Hu FB. Blood 25-hydroxy vitamin D levels and incident type 2 diabetes: a meta-analysis of prospective studies. Diabetes Care 2013 May:36(5):1422-8. PMC3631862.

6. Salinardi TC, Batra P, Roberts SB, Urban LE, Robinson LM, Pittas AG, Lichtenstein AH, Deckersbach T, Saltzman E, Das SK. Lifestyle intervention reduces body weight and improves cardiometabolic risk factors in worksites. Am J Clin Nutr 2013 Apr:97 (4): 667-76. PMCID: PMC3607649

7. Christakos S, Hewison M, Gardner DG, Wagner CL, Sergeev IN, Rutten E, Pittas AG, Boland R, Ferrucci L, Bikle DD. Vitamin D: beyond bone. Ann NY Acad Sci 2013 May:1387:45-58. PMC3717170.

8. Mitri J, Nelson J, Ruthazer R, Garganta C, Nathan DM, Hu FB, Dawson-Hughes B and Pittas AG. Plasma 25-hydroxyvitamin D and risk of metabolic syndrome: an ancillary analysis in the Diabetes Prevention Program. EJCN 2014:1- [PMID 24448494] [PMC Pending]

9. Mitri J, Pittas AG.Vitamin D and diabetes. Endocrinol Metab Clin North Am. 2014 Mar;43(1):205-32. PMCID:PMC3942667 [Available on 2015/3/1]

Last Updated on September 29, 2020