Insulin is the most powerful anabolic hormone in the body, transitioning it from the fasted to the fed state. The dysregulation of insulin signaling, or insulin resistance, plays a central role in the development of diabetes, cardiovascular disease and non-alcoholic fatty liver disease. In the liver, the gluconeogenic genes are key targets of insulin, and insulin suppression of the gluconeogenic genes is important for maintaining glucose homeostasis. However, numerous other targets exist. The mission of the Biddinger Lab is to define the other key targets of insulin and determine how they contribute to disease. We expect that our studies, by providing a more complete and granular understanding of insulin action, will lead to better therapies for insulin resistance and its sequelae.

Lab website