Melissa Putman, MD, MS

Institution: Massachusetts General Hospital
Research: Advancing the Diagnosis and Care of Cystic Fibrosis Related Diabetes
Grants & Publications: Harvard Catalyst
Categories: MGH

Leveraging the large patient population with cystic fibrosis (CF) cared for by the MGH CF Center and the Boston Children’s Hospital CF Center, the goal of this research program is to improve our understanding and treatment of CF-related diabetes (CFRD). With funding from the NIDDK and the Cystic Fibrosis Foundation (CFF), we are investigating the application of diabetes technology to the screening, diagnosis, and treatment of CFRD as well as the impact of nutrition on glycemic control and clinical outcomes. Utilizing resources from the clinical research core led by Dr. Nathan, we recently completed a clinical study investigating the use of continuous glucose monitoring (CGM) in the diagnosis of CFRD, finding that average glucose derived from CGM correlates well with A1c. We are also exploring the use of continuous glucose monitoring to the screening and diagnosis of CFRD. Funded by the NIDDK, we are leading studies investigating the safety and efficacy of artificial pancreas technology (the bionic pancreas) in children and adults with CFRD, with plans to expand our single-site clinical trial to multiple sites across the country with funding from the CF Foundation. We are also leading the Maternal and Fetal Outcomes in the Era of Modulators (MAYFLOWERS) CGM substudy, collecting comprehensive CGM data in pregnant women with CF throughout pregnancy at 30 CF centers across the US. We are also leading a multicenter planning grant to design a study investigating novel assessments of nutritional status in adults with CF and advanced lung disease. Lastly, funded by a competitive revision from the NIDDK to R01119699, we are investigating the use of CGM in hospitalized patients during the COVID-19 pandemic. This program has supported the career development of multiple junior investigators, including (1) Dr. Jordan Sherwood, a pediatric endocrinologist supported by CF Foundation Shwachman Career Development Award investigating artificial pancreas technology in patients with CF referred for lung transplant; (2) Dr. Laura Brenner, a pulmonologist awarded a K23 from the NIDDK investigating the impact of the bionic pancreas on lung and gut microbiome; (3) Dr. Luz Castellanos supported by a diversity supplement to R01DK119699; (4) Dr. Mollie Sands, a second year endocrine fellow at MGH, and (4) Dr. Kevin Scully, a pediatric endocrine junior faculty at Boston Children’s Hospital investigating diabetes technology in CFRD.