by Jason Fairchild | Sep 29, 2020 | Uncategorized
Systems biology approaches to understand human disease signaling networks The overall goal in the laboratory is to discover and understand the function of important mediators and effectors involved in innate (autophagy, phagocytosis) and adaptive (T cell...
by Jason Fairchild | Sep 29, 2020 | Uncategorized
Genetic Underpinnings of Hormonal Mechanisms Contributing to Cardiovascular Risk in Diabetes Mellitus For the past 20 years, we have studied the genetic underpinnings of hormonal factors leading to HTN and its associated CV risks. From these studies, we have...
by Jason Fairchild | Sep 29, 2020 | Uncategorized
High throughput methods to identify beta cell modulators Beta-cell death, and the consequent deficiency in insulin secretion, is a key feature of type 1 diabetes. For decades, the standard of care for this disease has been insulin therapy by intramuscular injection....
by Jason Fairchild | Sep 29, 2020 | Uncategorized
The biology of weight loss surgery Weight loss operations have become the gold standard therapy in our fight against the worsening obesity and type 2 diabetes (T2D) epidemics. An impressive observation has been the rapid resolution of T2D within days of surgery...
by Jason Fairchild | Sep 29, 2020 | Uncategorized
Transcriptional Basis Of Energy Metabolism In Health And Disease Our lab is focused on the regulation of energy homeostasis in mammals, primarily at the level of gene transcription. This includes the problems of fat cell development, control of metabolic rates and the...
by Jason Fairchild | Sep 29, 2020 | Uncategorized
Diabetes and Obesity Genetics in C. elegans and Mice Fat regulatory gene discovery in C. elegans. The lab uses the soil roundworm C. elegans in large-scale gene discovery screens to uncover and characterize genetic pathways involved in storage and...
