Ramnik Xavier, M.D., Ph.D

Systems biology approaches to understand human disease signaling networks  The overall goal in the laboratory is to discover and understand the function of important mediators and effectors involved in innate (autophagy, phagocytosis) and adaptive (T cell...

Gordon Williams, M.D.

Genetic Underpinnings of Hormonal Mechanisms Contributing to Cardiovascular Risk in Diabetes Mellitus For the past 20 years, we have studied the genetic underpinnings of hormonal factors leading to HTN and its associated CV risks.  From these studies, we have...

Bridget Wagner, PhD

High throughput methods to identify beta cell modulators Beta-cell death, and the consequent deficiency in insulin secretion, is a key feature of type 1 diabetes. For decades, the standard of care for this disease has been insulin therapy by intramuscular injection....

Ali Tavakkoli, M.D.

The biology of weight loss surgery Weight loss operations have become the gold standard therapy in our fight against the worsening obesity and type 2 diabetes (T2D) epidemics.  An impressive observation has been the rapid resolution of T2D within days of surgery...

Bruce M. Spiegelman, Ph.D.

Transcriptional Basis Of Energy Metabolism In Health And Disease Our lab is focused on the regulation of energy homeostasis in mammals, primarily at the level of gene transcription. This includes the problems of fat cell development, control of metabolic rates and the...