by Jason Fairchild | Sep 29, 2020 | Uncategorized
High throughput methods to identify beta cell modulators Beta-cell death, and the consequent deficiency in insulin secretion, is a key feature of type 1 diabetes. For decades, the standard of care for this disease has been insulin therapy by intramuscular injection....
by Jason Fairchild | Sep 29, 2020 | Uncategorized
The biology of weight loss surgery Weight loss operations have become the gold standard therapy in our fight against the worsening obesity and type 2 diabetes (T2D) epidemics. An impressive observation has been the rapid resolution of T2D within days of surgery...
by Jason Fairchild | Sep 29, 2020 | Uncategorized
Transcriptional Basis Of Energy Metabolism In Health And Disease Our lab is focused on the regulation of energy homeostasis in mammals, primarily at the level of gene transcription. This includes the problems of fat cell development, control of metabolic rates and the...
by Jason Fairchild | Sep 29, 2020 | Uncategorized
Diabetes and Obesity Genetics in C. elegans and Mice Fat regulatory gene discovery in C. elegans. The lab uses the soil roundworm C. elegans in large-scale gene discovery screens to uncover and characterize genetic pathways involved in storage and...
by Jason Fairchild | Sep 29, 2020 | Uncategorized
Inflammation in obesity and diabetes Accumulating evidence suggests that inflammatory cells, including macrophages, different subtypes of T cells, neutrophils, eosinophils, and mast cells all contribute to the development and progression of obesity and diabetes (1-7)....
