Gökhan S. Hotamisligil, M.D., Ph.D.

Molecular Mechanisms of Metabolic Syndrome Metabolic syndrome is a complex cluster of diseases including obesity, insulin resistance, type 2 diabetes mellitus, dyslipidemias, hypertension and cardiovascular disease. Yet the molecular mechanisms underlying these...

Steven Grinspoon, M.D.

Metabolic dysfunction in lipodystrophy and obesity This Program investigates critical question relating to the physiological regulation and clinical consequences of adipose tissue accumulation in models of obesity and acquired lipodystrophy. The research is aimed at...

Anna Greka, MD

Integrative Calcium Biology in Diabetes and Metabolic Disease Our laboratory is broadly interested in the biology of calcium signaling. Thousands of calcium channels on the cell’s plasma membrane precisely control the timing and entry of calcium ions. Calcium...

Robert E. Gerszten M.D.

Inflammation and Biomarkers in Cardiovascular Disease Dr. Gerszten’s research efforts focus on understanding the molecular basis of injury responses in cardiovascular disease. His laboratory has incorporated emerging proteomics and metabolomics technologies to help...

Jose C. Florez, M.D., Ph.D.

Gene Discovery and Pharmacogenetics of Type 2 Diabetes Dr. Florez’s research interests lie on the genetic determinants of type 2 diabetes and related metabolic traits, and how these variants may impact disease prediction and therapeutic choices.  Thus his...

Christiane Ferran MD, PhD

My laboratory has been involved in the fields of islet transplantation and vascular complications of diabetes. Based on unexpected recent results we developed an interest in exploring a novel insulin-independent anti-diabetic function of A20/TNFAIP3, an...